As previously mentioned, many diseases and conditions have genetic influences, but we question how an expression of certain genes may make an individual predisposed to developing Fibromyalgia and other arthritic conditions alike. One way we may explain this is through Genetic polymorphism. This  is the possession of more than one variation of  a gene; which may have arisen from a mutation. This polymorph gene then becomes more common in the general population (National Cancer institute); in other words is passed through generations. There are several polymorphic genes associated with FMS that impact upon the etiology of the condition. Fibromyalgia has been identified to have polymorphic genes involved in the dysregulation of neurotransmitters. Research over that past 20 years or so has identified polymorph genes of FMS. COMT is responsible for inhibition or breakdown of the neurotransmitters dopamine, noradrenaline and adrenaline. There are different types of variation in COMT activity, which can either result in lower or higher levels of COMT (Cohen et al.) in concordance with this we can assume that Fibromyalgia patients can inherit different variations which affects the symptoms they experience for example sleep disturbance or depleted moods. Marinez-Jauand et al, conducted research into the role of Catechol-O-methyltransferase (COMT) and its effect on the regulation of neurotransmitters. A variation in the COMT gene may alter this process, meaning a sufferer may have elevated or depleted levels of  dopamine. It is unclear at this stage in time whether levels of  these neurotransmitters are elevated or depleted.However, they found that a polymorphism of low COMT enzyme activity was significantly higher in FM patients compared to controls who were matched on genotyped polymorphisms (Martinez-Jauand et al., 2013). This suggests that FM patients may have elevated levels of dopamine, as there is a reduced inability of the COMT gene to  inhibit these neurotransmitters in the brain. Patients with lower COMT enzyme activity were found to have more pain sensation from thermal and pressure stimuli (Martinez-Jauand et al., 2013).

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