New Chemical Entities (NCEs) are of primary focus in
recent years, where they contribute in specific inhibition of the biological
process targeting the cancer cells with minimal or least effects on normal
cells. Major advantages of NCEs are they target cancer cells at the molecular
level to inhibit or down regulate the biological process to control cancer cell
proliferation. Thanks to the recent advances in cell biology which has provided
variety of immortal cancer cell lines to screen NCEs in particular cancer
models that mimic in vivo cellular growth.  On the other hand, advances in medical
chemistry have added many synthetic organic derivatives to be screened for
biological efficacy in cancer. Novel drug discovery using NCEs, in particular has gained momentum in
the scientific communities across different disciplines like cell biology,
biochemistry, pharmacology, hematology etc. Some of these compounds arise as
potential hits and add value to the novel drug discovery focusing effective,
economical, least toxic chemotherapeutics against cancer. 


indanones belong to a class of chemicals which closely resemble chalcones, added
with ?,?-unsaturated ketone to form a cyclic 5 membered ring. These small molecules
originate from 1-indanone and benzaldehydes through an
aldol reaction (Jose C, 2017). Due to their easy synthesis protocol and structural modifications, it
is possible to synthesize cost effective structural analogues of active
compounds. Arylidene indanones have demonstrated potential antitumor properties
by specific action on the inhibition of the various pathways canonically
providing the mechanistic fuel for the tumor or cancer development (Hari and
Pati, 2007). Indanones are shown to reverse the multi-drug resistance (MDR) in
cells caused by standard anticancer drugs and synergistically act with the
drugs to stop cancerous cell proliferation (Kars et al 2006). We have established
2-arylidene-4, 7-dimethyl indan-1-one to be effective against breast
adenocarcinoma cells by G2/M cell cycle arrest (Prasanna and Harish
2010). The same compound was also effective against lung cancer models by
inhibiting AKT enzyme. Our results suggest DNA damage-mediated activation by
this compound in lung cancer cells leading to extensive apoptosis through the
mitochondrial pathway. Many other potential uses of the Arylidene compounds are
reported, including its activity on Alzheimer’s diseases  (Hari and Pati, 2007).   

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