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These catechols are amino acid derivatives and probably syn­thesize in the cell from tyrosine amino acid by way of dihydroxy- phenylalanine and its decarboxylation product dopamine.

These are rapidly inactivated by the enzyme O-methyl transferees and possibly monoamine oxidase.

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Noradrenaline hormone differs from adrenaline in that the methyl group on the nitrogen is lacking. Both of these hormones contain an asymmetric carbon atom, and both naturally occur as D isomers.

D (—) adrenaline is about 15 times more potent than the synthetic L (+) isomer ; D (—) noradrenaline is 20 times more potent than its synthetic mirror image.

The proportion of adrenaline to noradrenaline varies from one species to another, and even within an individual from one circumst­ance to another.

Normally adrenaline is secreted 5 to 10 times the concentration of noradrenaline in the adrenal medulla but noradrena­line is also secreted by chromaffin tissue of sympathetic nervous system.

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